منابع مشابه
Immunolocalization of Galectin-3 in Mouse Testicular Tissue
Objective(s) Galectin-3 (Gal-3) is a member of the B-galactoside-binding lectins which is expressed in a variety of tissues and plays a role in diverse biological events, such as embryogenesis, adhesion, cellular proliferation, and apoptosis. In this study, the presence and distribution of galectin-3 (Gal-3) in the mouse testicular tissue was investigated. Materials and Methods Eight adult N...
متن کاملGalectin-3 in diabetic patients.
Galectin-3 is a versatile molecule which exerts several and sometimes opposite functions in various pathophysiological processes. Recently, galectin-3 has gained attention as a powerful predictor of heart failure and mortality, thus becoming a useful prognostic marker in clinical practice. Moreover, though not specifically investigated in diabetic cohorts, plasma levels of galectin-3 correlated...
متن کاملGalectin-3 in Cardiovascular Disease
In the context of a declining rate of deaths due to coronary atherosclerosis, the prevention and management of heart failure (HF) have an emerging dominant role in cardiovascular care. Prognosis with HF is poor, with about 50% 4-year mortality (1), and definitive treatment is challenging, related in part to the heterogeneity of causes. Biomarkers linked to the onset and progression of HF are no...
متن کاملThermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3.
Galectins are a growing family of animal lectins with common consensus sequences that bind beta-Gal and LacNAc residues. There are at present 14 members of the galectin family; however, certain galectins possess different structures as well as biological properties. Galectin-1 is a dimer of two homologous carbohydrate recognition domains (CRDs) and possesses apoptotic and proinvasive activities...
متن کاملThe role of galectin-3 and galectin-3-binding protein in venous thrombosis.
Galectin-3-binding protein (gal3bp) and its receptor/ligand, galectin-3 (gal3), are secreted proteins that initiate signaling cascades in several diseases, and recent human proteomic data suggest they may play a role in venous thrombosis (VT). We hypothesized that gal3bp and gal3 may promote VT. Using a mouse stasis model of VT, we found that gal3bp and gal3 were localized on vein wall, red blo...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2019
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2019.01.045